Protein or peptide name:ELA
Chromosome:1
Protein or peptide start site:NA
Protein or peptide end site:NA
ncRNA start site:19667947
ncRNA end site:19673896
Genome Browser:NA
Protein or peptide sequence:QRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP
Protein or peptide length:32aa
ncRNA type:ncRNA
ncRNA name:ELABELA (ELA)
Entrez ID:100536023
Experimental species:Danio rerio (zebrafish)
Experimental techniques:Immunofluorescence/western blotting/ RT-PCR/qPCR
Experimental sample (cell line and/or tissue):Naive ectodermal cells of the embryo
Description:We report here the discovery and characterization of a gene, ELABELA (ELA), encoding a conserved hormone of 32 amino acids.
Subcellular location:NA
Function:Loss of Ela causes embryos to develop with a rudimentary heart or no heart at all, surprisingly phenocopying the loss of the apelin receptor (aplnr), which we show serves as Ela cognate G protein-coupled receptor.
Title of paper:ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor
PMID:24316148
Year of publication:2013